Works on the church lasted throughout the century. They were completed in 1596 topping off the structure with a dome and a lantern. The three visible sides of the church are adorned in an almost identical way with pilasters and triangular, seemingly open pediments. Initially three entrances led into the church, preceded by steps. In the tympanum of one of them there is a small sculpture completed by Andrea Sansovino, depicting the Virgin and Child with the Blessed House of Loreto, which is a reference to the miracle, which was supposed to happen in this town. However, a true pearl in this church, is a fully completed octagonal dome set on a high tambourine. It is additionally decorated by an elaborate lantern known as the gabbia dei grilli (cricket cage), which is decorated with capitols with the images of human faces and burning torches. This lantern as well as the dome were designed by a student of the divine Michelangelo (Michelangelo Buonarroti) – Giacomo del Duca in 1582, becoming an important inspiration for subsequent generations of architects, including Francesco Borromini. Even if, the lantern is not the best of its types in Rome, it definitely is the most ornamental. On the other hand, the church’s bell tower, situated between one of the façades and the building of the Guild of Bakers, from the XIX century, appears to be a work of lesser quality.

The following century (XVII century) brought about the furnishing of the interior, which in the middle of the XIX century underwent thorough modernization. The church possesses four semi-circular chapels and a presbytery which ends with an apse. The most interesting of these is the space of the presbytery, additionally illuminated by a small lantern in its vault. The altarpiece from the beginning of the XVI century depicts Our Lady with St. Sebastian and St. Roch. On either side there are very interesting canvases of a valued painter of the first half of the XVII century – Cavaliere d’Arpino (Giuseppe Cesari): The Birth and Death of Our Lady (1630). The walls richly decorated with marbles are supplemented by statues – two angels the farthest from the altar are the works of Stefano Maderno, the very same one who sculpted the famous statue of the deceased St. Cecilia in the Church of Santa Cecilia on the Trastevere. The remaining ones depict holy virgins, while their authors were renowned Baroque sculptors – Giuliano Finelli (St. Cecilia), Pompeo Ferrucci (St. Agnes), François Duqesnoy (St. Susanna) and Domenico de Rossi (St. Flavia). A contemporarily added small chapel leads away from the presbytery devoted to the Madonna of Loreto.

The interior of the octagonal dome covering the whole church, is filled with representations of prophets, sibyls, saints, and angels accompanying them. They were created in the XIX century.

Apart from the most valuable artistically, already mentioned objects found in the presbytery, we will not find many interesting works of art within the church. However, here a some of them:

•     Chapel of St. Catherine of Alexandria (first on the right) – the mosaics found within are from the end of the XVI century, and are a work of Paolo Rossetti.
•       Chapel of the Magi (second on the right) – it is adorned mainly with decorations of the popular fresco artist from the end of the XVI century Pomarancio (Niccolò Circignani). In the main altar is the scene of The Adoration of the Magi (1586). On both of its sides, on the outer walls of the pilasters, we will notice images of the chapel founders – the Marzettis, awaiting for the support of the faithful coming into the church
•     The Crucifix Chapel (second on the left) – the XVI-century wooden cross found within, set in an elaborate way into a frame, in which the relics of saints are stored.

This church is generally omitted during walks around Rome and tourists who are exhausted with a plethora of sensations seldom visit it, despite the fact that it is located in the very heart of the city near Trajan’s Forum. It is accompanied by another, nearly identical church situated nearby – the Santissimo Nome di Maria al Foro Traiano.